Summary of Product Characteristics (SPC)

There is no data concerning post exposure prophylaxis with TicoVac 0.5 ml.As with all vaccines, TicoVac 0.5 ml may not completely protect all vaccinees against the infection that it is intended to prevent. Should a severe adverse event occur, the patient must immediately stop Copaxone treatment and contact his/her physician or any emergency doctor. Daunorubicin should be used under the direction of a clinician conversant with the management of acute leukaemia and cytotoxic chemotherapy. In clinical trials, patients were administered aciclovir 200 mg twice a day or equivalent. For instructions on preparation, see section 6.6. A similar syndrome has also been reported rarely following withdrawal of amantadine and other anti-parkinson agents in patients who were not taking concurrent psychoactive medication.Resistance to amantadine occurs during serial passage of influenza virus strains in vitro or in vivo in the presence of the drug.

Suppression of the inflammatory response and immune function increases the susceptibility to fungal, viral and bacterial infections and their severity. If corticosteroids have been stopped following prolonged therapy they may need to be temporarily re-introduced.Use with caution in patients with myasthenia gravis, non-specific ulcerative colitis, diverticulitis and fresh intestinal anastomoses.Special precautions: Particular care is required when considering the use of systemic corticosteroids in patients with the following conditions and frequent patient monitoring is necessary.A. Patients treated with Enbrel should be given the Patient Alert Card.Enbrel is available in strengths of 10, 25 and 50 mg. Imuran is contra-indicated in patients known to be hypersensitive to azathioprine. In the treatment of graft rejection reactions following transplantation, a dose of up to 1 g/day may be required. In such patients the metabolism of Imuran may be impaired, and the dosage of Imuran should therefore be reduced if hepatic or haematological toxicity occurs.Limited evidence suggests that Imuran is not beneficial to patients with hypoxanthine-guanine-phosphoribosyltransferase deficiency (Lesch-Nyhan syndrome).

Patients (or parents of children) without a definite history of chickenpox should be advised to avoid close personal contact with chickenpox or herpes zoster and if exposed they should seek urgent medical attention. Injection directly into tendons. In total: 8 cycles.MabThera is administered on day 1 of each chemotherapy cycle after intravenous infusion of the glucocorticoid component of CHOP.Safety and efficacy of MabThera have not been established in combination with other chemotherapies in diffuse large B cell non-Hodgkin’s lymphoma. If a diagnosis of chickenpox is confirmed, the illness warrants specialist care and urgent treatment. Patients/and or carers should be warned that potentially severe psychiatric adverse reactions may occur with systemic steroids (see section 4.8). Chicken pox and measles, for example, can have a more serious or even fatal course in non-immune children or adults on corticosteroids.Chickenpox is of serious concern since this normally minor illness may be fatal in immunosuppressed patients.

Rheumatic disorders: some cases or specific forms (Felty’s syndrome, Sjögrens syndrome) of rheumatoid arthritis, including juvenile rheumatoid arthritis, acute rheumatism, lupus erythematosus disseminatus, temporal arteritis (polymyalgia rheumatica). Adrenal function should be monitored throughout. In rheumatoid arthritis, maintenance steroid therapy should be at the lowest possible level.In alternate-day therapy, the minimum daily corticoid requirement is doubled and administered as a single dose every other day at 8.00 am. Human Varicella-Zoster Immunoglobulin does not prevent infection even if given within 72 hours of exposure, but may attenuate an attack if given within 10 days after exposure. RoActemra can be given as monotherapy (in case of intolerance to MTX or where treatment with MTX is inappropriate) or in combination with MTX.RoActemra in combination with methotrexate (MTX) is indicated for the treatment of juvenile idiopathic polyarthritis (pJIA; rheumatoid factor positive or negative and extended oligoarthritis) in patients 2 years of age and older, who have responded inadequately to previous therapy with MTX. And I think the reason for this is everyone is under the false assumption that the herpes simplex virus is not curable.

Symptoms of ITP could include (but are not limited to) easy bruising, petechiae, spontaneous mucocutaneous bleeding (e.g., epistaxis, haemoptysis), heavier than normal or irregular menstrual bleeding. Increased appetite. Patients (or parents of children) without a definite history of chickenpox should be advised to avoid close personal contact with chickenpox or herpes zoster and if exposed they should seek urgent medical attention. Three-year safety data in renal and cardiac transplant patients did not reveal any unexpected changes in incidence of malignancy compared to the 1-year data.

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